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2019年

立足本土求创新,深耕细作讲“骨”事​——对话大数据精准医疗高精尖中心王晓刚团队

随着我国老龄化的加速,50岁以上人群骨质疏松症患病率高达19.2%。北京航空航天大学大数据精准医疗高精尖中心的王晓刚团队及其合作团队跨界协作的最新研究成果,为众多骨质疏松患者带来了福音。该成果“The long noncoding RNA lnc-ob1 facilitates bone formation by upregulating Osterix in osteoblasts ”(成骨细胞中的lnc-ob1上调Osterix促进骨形成)于北京时间2019年4月8日在线发表在了《Nature Metabolism》上,这是该杂志首次以中国学者为通讯单位发表的研究类论文。

WANGXIAOGANG,YANJIUYUAN。ZHANGQICONGSHIGUTUIXINGXINGBINGBIANJINGZHUNYIXUEYANJIU。JINNIANLAIJIANLIQIYITAOWANZHENGDEHESUANYAOWUBADIANSHAIXUAN—HESUANYAOWUXIBAOTEYIXINGDISONG—HESUANBADIANZHUANHUAYINGYONGDEYANJIUTIXI。ZUOWEITONGXUN/DIYIZUOZHEFABIAOSCILUNWEN28PIAN,DAIBIAOXINGLUNWENFABIAOZAINature Medicine、Nature Metabolism、ACS Nano、Nature Communications、JBMRDENGGUOJIQUANWEIKANWU(QUANBUZAIGUONEIWANCHENG),HUO2017NIANJIJINWEIYOUQINGXIANGMUZIZHU。

生物学新晋热门领域剑指医学瓶颈

GUZHISHUSONGDEFASHENGFAZHANHECHENGGUXIBAODEHUOXINGMIQIEXIANGGUAN,YANJIUXIANSHICHENGGUXIBAONENGLIXIAJIANGSHIGUZHISHUSONGFABINGDEZHUYAOYUANYINZHIYI。MUQIANYINGYONGYULINCHUANGWEIYIGAOXIAOCUJINCHENGGUXIBAOGONGNENG、JIASUGUXINGCHENGYAOWUSHIJIAZHUANGPANGXIANJISU(JIANCHENGPTH),DANGAIYAOWUCUNZAIZHELIANGNIANSHIYONGSHIXIAN、ZHILIAOGUZHEXIAOGUOYOUXIAN、QIANZAIGUROULIUFENGXIANDENGBIDUAN。SUOYI,GUXINGCHENGYAOWUDEKAIFA“PINGJING”JIXUXINDECELVELAIJIEJUE。

电竞大师WEILEXUNZHAOXINDEGUZHISHUSONGQIANZAIZHILIAOFANGAN,WANGJIAOSHOUJIQITUANDUIJIANGMUGUANGTOUXIANGLEZHANGFEIBIANMARNA (IncRNA)LINGYU。ZUOWEISHENGWUTINEISHULIANGZUIDUODERNALEIXING,YUELAIYUEDUODEIncRNABEIFAXIANKEYIYINGXIANGXIBAODEGONGNENG、QIGUANDEFAYUYIJIDUOZHONGJIBINGDEFASHENGFAZHAN。DANSHIIncRNAZAIJIBINGZHONGDEGONGNENGHEZUOYONGJIZHIMUQIANSHANGBUMINGQUE。IncRNASUIBEIZHENGMINGZAITIWAIYANJIUXITONGZHONGCANYULECHENGGUXIBAODECHENGSHUHEQIQIANTIXIBAO-JIANCHONGZHIGANXIBAODECHENGGUFENHUA,DANSHIFOUNENGZAITINEIYINGXIANGGUDAIXIE、DIAOJIEGUXINGCHENGHAIBUQINGCHU。NENGFOUZAIZHONGDUODEHOUXUANIncRNAZHONGFAXIANZAITINEICUJINCHENGGUDEBAOSHOUXINGlncRNAFENZI,JINERJIANGlncRNAZUOWEIGUZHISHUSONGZHENGGANYUDEQIANZAIBADIAN,SHIBENLINGYUJIDAIJIEJUEDEWENTI。ZHEIYECHENGWEILEWANGJIAOSHOUTUANDUIKEXUEYANJIUDEZHUGONGDEFANGXIANG。

多方合作,攻坚克难

电竞大师YANJIUSHELIEFANWEIJIAOGUANG,JUTISHEJIDAODASHUJUZHUANLUZUXUE、FENZISHENGWUXUEDENGXUEKE,SHIWOGUOSANGEYOUQINGTUANDUIJINGCHENGHEZUO、LIANHEGONGGUANDEJIEGUO。QIZHONGJINANDAXUEDEZHANGGONGJIAOSHOUJIEJUELEHOUXUANBADIANSHAIXUANDENANTI;TONGJIDAXUEDESUNYAOJIAOSHOUXITONGERWANSHANDIPINGJIALEJIYINGONGCHENGXIAOSHUDEGUBIAOXING;DIANJINGDASHIWANGXIAOGANGJIAOSHOUSHANZHANGGUBINGLISHENGLIXUE、FENZIXIBAOSHENGWUXUE、DONGWUYICHUANXUEHEYAOWUDISONGZAITIGOUJIAN,ZHAODAOLEQIADANGDEJIBINGGUOCHENGHEGUANJIANDEYANJIUDUIXIANG,BINGSHENRUTANTAOLEYAOWUFAHUIZUOYONGDEJIZHI,GOUJIANLECHENGGUBAXIANGDEYAOWUDISONGZAITI,SHIXIANLEYAOWUBADIANDEFAXIAN、YANZHENGHEYINGYONGDEGUZHISHUSONGJINGZHUNZHILIAO。

YANJIUDEGUANJIAN——FAXIANlnc-Ob1SHIYIGEJIANNANQUZHEDEGUOCHENG。TUANDUIXIWANGZHAODAOCHENGGUXIBAOTEYIXINGDEBADIANFENZI,CONGGENBENSHANGZENGJIAGULIANGDUIKANGGUZHISHUSONG。WEICI,TUANDUISHIYONGXIAOSHUHERENDEBMSCs(bone marrow stem cells,GUSUIJIANCHONGZHIGANXIBAO)FENHUAMOXING,LIYONGLIANTEYIXINGJIANKUJISHUDUIFENHUAQIANHOUDEXIBAOJINXINGZHUANLUBENCHAOGAOSHENDUCEXU,HUODELE600YUGDEYUANSHISHUJU(XIANGDANGYUYIBANCESHIDE200BEISHUJULIANG),RANHOULIYONGTUANDUIZIZHUYANFADEFANSe3SUANFAJINXINGFENXI。TONGGUODUIZHEIXIECHAYIBIAODADElncRNAJIYINZAIXULIEXIANGSIXING、SHIXUBIAODA、JIYINZUZHIDENGDUOFANGMIANJINXINGDEXITONGPINGGU,KETIZUJIANDINGDAOYIGERENHEXIAOSHUCHENGGUXIBAOZHONGDOUTEYIXINGSHANGDIAODElncRNAFENZI(MINGMINGWEIlnc-Ob1/lnc-OB1)。JINYIBUYANJIUBIAOMING,ZAILAONIANRENCHENGGUXIBAOZHONGlnc-OB1DEBIAODAFASHENGZENGLINGXINGXIADIAO;QULUANCHAOHELAONIANXIAOSHUCHENGGUXIBAOZHONGlnc-Ob1DEBIAODAYEFASHENGXIANZHUXIADIAO。RUSHANGJIEGUOTISHIlnc-Ob1HENKENENGYUGUXINGCHENGYOUMIQIEGUANXI,BINGQIEZAIGUZHISHUSONGFASHENGFAZHANGUOCHENGZHONGYOUZHONGYAODEDIAOKONGZUOYONG,ZHEIJIANGWEIZHILIAOGUZHISHUSONGTIGONGYIZHONGQIANZAIDEXINFANGAN。

XIANGBIJIAZHUANGPANGXIANJISUPTH,TUANDUIFAXIANDElnc-Ob1SHIYIGECHENGGUXIBAOTEYIXINGBIAODADEFENZI,DUIQITAZUZHIXIBAODEZUOYONGHENRUO,YUNYONGTUANDUIGOUJIANDECHENGGUXIBAOBAXIANGDISONGJISHU,KEYIBAFUZUOYONGJIANGDAOHENDIDESHUIPING。CIWAI,TUANDUICONGQUANXINDEJIAODUSHENRUFAJUEYAOWUBADIAN,JIANGDUIRENLEIJIBINGDEZHILIAODAILAIGEMINGXINGDECUJINZUOYONG。

家国情怀,服务社会

WEILERANGYANJIUCHENGGUOJINKUAITOURULINCHUANG,TUANDUIXIAYIBUGONGZUODEGUANJIANDIANHENANDIANJIANGFENXIJIYUlnc-OB1BAXIANGJIYINZHILIAODEANQUANXING。TONGSHI,lncRNASHIYIZUOSHENGWUYIXUEYANJIUDEFUKUANG,TUANDUIHAIJIANGDUICIQIANYANJIUZHONGFAXIANDEDALIANGHOUXUANFENZIJINXINGSHENRUYANJIUYUYANZHENG。WANGJIAOSHOUQIANGDIAO,ZHIYOUZAIQUEBAOANQUANXINGDEQIANTIXIA,YOUYIDELIAOXIAOCAISHIYOUYIYIDE。GUZHISHUSONGZUOWEILAONIANTUIXINGXINGJIBING,KEYIYANHUANERBUNENGNIZHUAN。DANSHIJINLIANGJIANGDIGUZHISHUSONGGUZHEDEFASHENGGAILV,TIGAOGUZHISHUSONGHUANZHEDESHENGHUOZHILIANG,SHIYIXUEGONGZUOZHEYINGGAINULIDEFANGXIANG。

电竞大师GAODUZHONGSHIHUANZHEXUQIU,YUWANGJIAOSHOUQIANGLIEDEJIAGUOQINGHUAIHESHEHUIZERENGANMIBUKEFEN。ZUOWEIYIMINGTUSHENGTUZHANGDEBENGUOXUEZHE,TAYIZHIXIWANGKETIZUDETONGXUENENGWEIZUGUODEFAZHANFENGXIANLILIANG。MIANDUIDANGQIANJUEDADUOSHUYAOWUBEIGUOWAILONGDUANJIGUOJIADAILAIJUDAFUDANDEQINGKUANG,TASHENGANTONGXIN。TAREQIEDIBIAOSHIKEYANGONGZUOZHEZAIZHENGSHIGUOJICHAJUDETONGSHI,YEYINGGAIYOUMINZUZIXINXIN。“DIANJINGDASHIDEYINGJIANPINGTAIYIJINGBUBIGUOWAISHIYANSHICHA,DIANJINGDASHIXUYAOYIZHONGXIONGHUAITIANXIA,JIANCHIBUXIEDEJINGSHEN,LIZUGUONEI,ZUOBEIHANGTESEDEJINGZHUNYILIAO,JIJIRONGRUXUEXIAOFAZHANDEDAQUSHI,NULICHENGWEISHENGWUYIYAOCHANXUEYANFAZHANDENONGCHAOER。”

 

电竞大师WENAN: LIXINXIN SHEJI: YANGYANZHUO

电竞大师TEBIEMINGXIE: SHUJUJINGZHUNYILIAOGAOJINGJIANZHONGXIN

CHUPIN: BEIHANGMENHUWANGZHANZONGBIANZONGJIANGONGZUOSHI

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